Overview

Pharmacokinetics are fundamental throughout drug discovery and development. The assessment of the pharmacokinetic profile on new chemical entities reduces the failure during development making the process more efficient.

The webinar reviews the general concepts and basic elements of pharmacokinetics. The webinar will describe the processes that a drug undergoes after administration such as the absorption (when not administered intravenously), the distribution, including plasma protein binding, the metabolism (the biotransformation of the drug into its metabolites) and the excretion (via the bile in faces and via the kidney in urine). The use of PK during drug development will also be described. PK studies can facilitate knowledge management and decision making to streamline drug discovery and development and to reduce the attrition rate.

Why Should You Attend

To get a better understanding of the different aspects that contribute to the pharmacokinetic profile of a new chemical entity. PK studies asses drug exposure to facilitate drug development. PK studies offer great support to learn and confirm the key characteristics of new molecular entities in a quantitative manner. This provides evidences for optimizing drug development plans and enabling critical decision-making. Drug development without PK is considered at a higher risk of failure.

Webinar Takeaway

  • Absorption
  • Distribution
  • Metabolism
  • Excretion
  • Volume of distribution
  • Plasma protein binding
  • Clearance
  • Elimination half-life

Who Will Benefit

  • Project managers,
  • Pre-clinical and clinical pharmacologists,
  • Regulatory affairs,
  • Clinical research associates,
  • Drug discovery scientists,
  • Contract research organizations,
  • Medical writers
  • Graduate students willing to enter the drug R&D sector.
FDA Faculty Dr. Stefano Persiani

Faculty Dr. Stefano Persiani 

Internal & External Innovation, Director Translational Sciences and Pharmacokinetics at Rottapharm Biotech

Italy

Dr. Stefano Persiani is currently Director of Translational Sciences and Pharmacokinetics at Rottapharm Biotech, Italy. He graduated in Pharmacy at the University of Milan, Italy and completed a Post-Doctoral fellowship in the Department of Pathology of the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA, and later as a Research Associate in the Department of Pharmaceutics of the University of Southern California, School of Pharmacy in Los Angeles, California, USA. After these academic positions, he entered the pharmaceutical industry at Farmitalia Carlo Erba, Pharmacia, Upjohn, and Zambon Group and in the CRO sector as Scientific Director for Clinical Pharmacology

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